Triethyl Orthoformate

Triethyl Orthoformate - Names and Identifiers

Name	Triethyl Orthoformate
Synonyms	triethoxy-methan ethoxymethanediol Ethyl orthoformate Ethyl formate(ortho) Triehyl orthoformate Triethyl Orthoformate Triethyl Orthoformate (TEOF) Orthoformic acid triethyl ester Triethyl ester of Orthoformic acid Triethylester kyseliny orthomravenci 1,1',1''-[methylidynetris(oxy)]tris-ethan 1,1',1''-[methylidynetris(oxy)]tris-Ethane Ethane,1,1',1''-[methylidynetris(oxy)]tris- Ethane, 1,1',1''-[methylidynetris(oxy)]tris-
CAS	122-51-0
EINECS	204-550-4
InChI	InChI=1/C3H8O3/c1-2-6-3(4)5/h3-5H,2H2,1H3
InChIKey	GKASDNZWUGIAMG-UHFFFAOYSA-N

Triethyl Orthoformate - Physico-chemical Properties

Molecular Formula	C7H16O3
Molar Mass	148.2
Density	0.891 g/mL at 25 °C (lit.)
Melting Point	-76 °C (lit.)
Boling Point	146 °C (lit.)
Flash Point	86°F
Water Solubility	1.35 g/L
Vapor Presure	2.9 mm Hg ( 20 °C)
Vapor Density	5.11 (vs air)
Appearance	Liquid
Color	Clear colorless
Merck	14,6884
BRN	605384
Storage Condition	Flammables area
Sensitive	Moisture Sensitive
Refractive Index	n20/D 1.391(lit.)
Physical and Chemical Properties	Characteristics of colorless liquid, irritating odor.
Use	Used as pharmaceutical raw materials, it is the synthetic raw materials of antimalarial drugs such as chloroquine and quinquine. It is also used in the preparation of high polymers, photographic drugs, photosensitive materials, anti-Halo dyes, cyanine dyes and synthetic pesticides.

Triethyl Orthoformate - Risk and Safety

Hazard Symbols	Xi - Irritant
Risk Codes	R10 - Flammable R36 - Irritating to the eyes R36/38 - Irritating to eyes and skin.
Safety Description	S16 - Keep away from sources of ignition. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S37/39 - Wear suitable gloves and eye/face protection S36 - Wear suitable protective clothing. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) S36/39 -
UN IDs	UN 2524 3/PG 3
WGK Germany	1
RTECS	RM6475000
FLUKA BRAND F CODES	21
TSCA	Yes
HS Code	29159080
Hazard Class	3
Packing Group	III
Toxicity	LD50 orally in rats: 7.06 g/kg (Smyth)

Triethyl Orthoformate - Upstream Downstream Industry

Raw Materials	Sodium Trichloromethane Ethyl Alcohol Sodium ethoxide
Downstream Products	Diethyl ethoxymethylenemalonate Amitraz Ciprofloxacin Chloroquine diphosphate

Triethyl Orthoformate - Nature

Open Data Verified Data

colorless liquid with pungent odor. The relative density was 0.8909. Melting point <-18 °c. Boiling point 143 C (102kPa). Flash point 27 °c. Refractive index 3900. Miscible with ethanol and ether. Slightly soluble in water, but will decompose in water.

Last Update：2024-01-02 23:10:35

Triethyl Orthoformate - Preparation Method

Open Data Verified Data

The sodium ethoxide method uses sodium ethoxide and chloroform as raw materials to react at 60 to 65 ° C. To produce a crude triethyl orthoformate, which is then fractionated to obtain a finished product.
ethanol method to ethanol and sodium hydroxide instead of sodium ethoxide, the use of solid-liquid phase transfer catalysis, the catalyst for PTC.
benzoyl chloride method with benzoyl chloride, formamide and anhydrous ethanol as raw materials, under the action of Catalyst, the formation of triethyl orthoformate, benzoic acid and ammonium chloride mixture, the separation of the finished product of triethyl orthoformate and benzoic acid.

Last Update：2022-01-01 10:33:51

Triethyl Orthoformate - Use

Open Data Verified Data

pharmaceutical raw materials, is the antimalarial drugs chloroquine, quinquine and other synthetic raw materials. It is also used in the manufacture of polymers, photographic drugs, photosensitive materials, anti-Halo dyes, cyanine dyes and synthetic pesticides.

Last Update：2022-01-01 10:33:50

Triethyl Orthoformate - Safety

Open Data Verified Data

The toxicity of this product is very low, and the oral LD50 of rats is 7.06g/kg.
This product is packaged in an iron drum, and the barrel mouth should be sealed. According to the general provisions of the storage and transportation of chemicals.

Last Update：2022-01-01 10:33:51

Triethyl Orthoformate - Reference Information

LogP	1.2 at 20℃
NIST chemical information	information provided by: webbook.nist.gov (external link)
EPA chemical substance information	information provided by: ofmpeb.epa.gov (external link)
Introduction	triethyl orthoformate is colorless liquid with pungent odor. Miscible with ethanol and ether. Slightly soluble in water, but will decompose in water. It is a very important chemical raw materials, has been widely used in medicine, pesticides, dyes and other industries.
Application	triethyl orthoformate in medicine, widely used in the synthesis of chloroquine, quinquine, dichloroquinoline, norfloxacin, ciprofloxacin, flupilinic acid, aminopyrimidine, and the like. In the aspect of pesticide, it is widely used in the production of azoxystrobin, pyridoxine, pyrisulfuron-methyl, chlorpyrisulfuron, tetrazolsulfuron-methyl, bicusponil and Amitraz, etc. Triethyl orthoformate is also an intermediate for acrylic fibers and methine dyes and is used in the synthesis of cyanine dyes. Triethyl orthoformate can also be used as some development sensitive agents, and is widely used as an anti-halation material in photographic drugs and color film and other photosensitive materials.
Use	triethyl orthoformate is an intermediate of the acaricide amitraz and the herbicide pyrisulfuron-methyl, and can also be used in the preparation of antimalarial drugs chloroquine, drugs such as quinquine. used as raw materials for the preparation of antimalarial drugs chloroquine, quinquine and photographic agents, photosensitive materials, also used in the synthesis of methaquine and cyanine dyes used in organic synthesis used as pharmaceutical raw materials, is the antimalarial drugs such as chloroquine and quinpa synthesis raw materials, also used in the preparation of high polymer, photographic drugs, photosensitive materials, anti-Halo dyes, cyanine dyes and synthetic pesticides.
production method	the preparation method is to add chloroform into the reaction kettle, stir and heat to 55 ℃, sodium ethoxide ethanol solution was added dropwise, and the reaction temperature was controlled at 60~65 ℃. After addition, the temperature was gradually increased to 70 ℃, and the temperature was maintained for 1H. At the end of the reaction, the pH was <8, and sodium chloride was filtered off, the filtrate was fractionated to obtain a crude product, which was then subjected to rectification to obtain a finished product. 3C2H5ONa CHCl3 → CH(OC2H5)3 3NaCl 1. Sodium ethoxide method with sodium ethoxide and chloroform as raw materials, reaction at 60-65 ℃ to produce crude triethyl orthoformate, and then refined by fractionation to get the finished product. Ethanol method sodium ethoxide was replaced by ethanol and sodium hydroxide. PTC was used as catalyst by solid-liquid phase transfer catalysis. Benzoyl chloride method with benzoyl chloride, formamide and anhydrous ethanol as raw materials, under the action of Catalyst, the formation of triethyl orthoformate, benzoic acid and ammonium chloride mixture, the separation of the product of triethyl orthoformate and benzoic acid.
category	relatively flammable liquid
toxicity grade	poisoning
Acute toxicity	inhalation-rat LCL0: 4000 PPM/8 h
stimulation data	Skin-rabbits 10 mg/24 h mild; eye-rabbit 100 mg/24 h moderate
flammability hazard characteristics	in case of open flame, high temperature, flammable oxidant; Combustion stimulus smoke
storage and transportation characteristics	The warehouse is ventilated and dried at low temperature; It is stored separately from the oxidant
extinguishing agent	dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent

Last Update：2024-04-09 19:05:07

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Triethyl Orthoformate

Triethyl Orthoformate

CAS: 122-51-0

Molecular Formula: C7H16O3

Triethyl Orthoformate - Names and Identifiers

Triethyl Orthoformate - Physico-chemical Properties

Triethyl Orthoformate - Risk and Safety

Triethyl Orthoformate - Upstream Downstream Industry

Triethyl Orthoformate - Nature

Open Data Verified Data

Triethyl Orthoformate - Preparation Method

Open Data Verified Data

Triethyl Orthoformate - Use

Open Data Verified Data

Triethyl Orthoformate - Safety

Open Data Verified Data

Triethyl Orthoformate - Reference Information

Supplier List

Triethyl Orthoformate Request for Quotation

Triethyl Orthoformate

CAS: 122-51-0

Molecular Formula: C7H16O3

Triethyl Orthoformate - Names and Identifiers

Triethyl Orthoformate - Physico-chemical Properties

Triethyl Orthoformate - Risk and Safety

Triethyl Orthoformate - Upstream Downstream Industry

Triethyl Orthoformate - Nature

Open Data Verified Data

Triethyl Orthoformate - Preparation Method

Open Data Verified Data

Triethyl Orthoformate - Use

Open Data Verified Data

Triethyl Orthoformate - Safety

Open Data Verified Data

Triethyl Orthoformate - Reference Information

Supplier List

Triethyl Orthoformate